Description
Assistant Project Scientist University of California Los Angeles Requisition Number: JPF10589 The Project Scientist’s research will focus on defining innate and adaptive immune dysregulation in immunosuppressed transplant recipients following SARS-CoV-2 vaccination. Specifically, they will investigate how immunosuppressive therapies, particularly mycophenolate mofetil (MMF), affect the magnitude, quality, and durability of both cellular and humoral immune responses in kidney transplant patients. Using validated assays, the candidate will quantify and functionally profile these immune responses and employ systems biology approaches to characterize the peripheral immune landscape at the single-cell level prior to vaccination. This work aims to identify pre-vaccine immunological predictors of protective immunity and to uncover the mechanisms by which MMF impairs vaccine-induced immune responses. The candidate will assess how pre-vaccine MMF dose reduction influences the immune response to SARS-CoV-2 booster vaccination in solid organ transplant recipients. The applicant must have a PhD or MD/PhD with at least 5 years of post-doctoral experience in immunology. Proficiency in multicolor flow cytometry, immune cell functional assays, cytokine bead arrays, cell isolation and culture techniques, as well as single-cell RNA sequencing is required. Interested applicants, please apply via this link: https://recruit.apo.ucla.edu/JPF10589 To apply, please visit: https://recruit.apo.ucla.edu/JPF10589 The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction jeid-7f0ffcb303576d4ca28a0e1d87840ef1